Structure-based design efforts for the lead/late-stage optimization of small molecule therapeutics across a range of therapeutic areas Play a key role in prioritizing medicinal chemistry efforts through critical analysis and effective decision-making leading to highly focused work and rapid progress. Ensure the timely delivery of data and results to project teams to enable rapid iterative design cycles Maintain critical timelines and set team expectations for efficient delivery of clinical candidates Work closely with other discovery scientists to move our portfolio of molecules from leads to quality drug candidates that have a strong potential to become breakthrough drugs Basic Requirements: PhD in Chemistry, Biophysics or related disciplinewith 0 to 5 years of Drug Discovery research experience. Additional Preferences: A scientific background in computational chemistry and related technology applied to guide compound optimization for medicinal chemists. Proactive and effective collaboration with medicinal chemistry, structural biology, and other disciplines to achieve project goals and timelines Strong core desire to help patients in need. Deep-thinking that leads to creative hypotheses for the optimization of lead series across multiple projects. A strong desire to establish a deeper understanding of all aspects of drug discovery, including small molecule-protein interactions, ADME, and toxicological considerations. A desire to continually stay up to date with the latest industry developments and novel techniques employed in discovery including AI and machine learning models. A proactive and highly engaged approach to solving challenging problems in discovery is essential Knowledge of lead optimization using structure-based design and other aspects of computational chemistry Agility and adaptability to change research priorities as necessary for success. Physical Demands/ Travel: The physical demands of this job are consistent with an office environment. The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Travel may be required. Work Environment: This is an onsite position located in one of the established Lilly med chem sites in San Francisco, California or Louisville, Colorado. The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. - To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.