PAT responsibilities:Developing PAT methods (multivariate data analysis and spectroscopic methods) and data models to support unit manufacturing operations. Implementation of PAT methods/models for real time in-process controls and real time release testing. Implementation of automated control strategies to support continuous GMP manufacturing including configuration, bench testing, integrated script testing, report development, and report validation. Supporting GMP continuous manufacture, including leading PAC activities in support of clinical manufacturing. Qualification and maintenance of PAT equipment. Dissolution responsibilities:Supporting analytical method development, validation, and transfer. Develops, troubleshoots, and conducts analytical experiments in support of drug substance/product process development within SOPs and regulations. Collates and interprets complex analytical data systematically, and compiles results into a cohesive body of conclusions or recommendations to guide Project decisions and new analytical activities. Authors methods, protocols and reports as assigned. Maintains accurate records of experiments and results in an electronic laboratory notebook. Demonstrates knowledge of scientific principles and basic understanding of applicable drug development regulations. Knowledge and Skills:Knowledge and experience in one or more analytical techniques (e.g. Spectroscopic techniques, particle size measurement, HPLC/ UPLC, Dissolution testing, KF, etc.)Excellent experimental documentation, and ability to exercise sound scientific and technical judgment. Excellent attention to detail and strong communication skills. The ability to work successfully in both a team/matrix environment as well as independently. The ability to work in a fast-paced environment, manage priorities, and maintain timelines for multiple projects. Demonstrated skills with a scripting language and/or multivariate analysis software (e.g. Matlab, VBA, Python, Aspen Unscrambler)Excellent ability to analyze, visualize, and interpret data. Experience with regulatory requirements and industry standards, including cGMP - Education and Experience:A PhD. degree in Chemistry, Chemical Engineering or Pharmaceutical Chemistry and 0-3 years’ experience or a Masters and 2-5 years experience or Bachelor's degree and 6 years of experience of relevant analytical experience. Pay Range:$99,400 - $149,000 Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation:Hybrid-Eligible Or On-Site Eligible. Flex Eligibility Status:In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information. Vertex is a global biotechnology company that invests in scientific innovation.