The HTA, Value & Evidence Senior Manager is responsible for development and execution of high-quality HV&E strategic efforts to support optimal access and reimbursement for treatments in Rare Disease. This role directly impacts business objectives on a global basis by providing strategic guidance and robust evidence development relevant to achieve optimal global patient access by demonstrating the value of Rare Disease medicines. This position will be part of Pfizer’s dynamic US Medical Affairs/ HV&E team and will have the important role of managing health economics and outcomes research (HEOR) to generate data to support patient access to Rare Disease with a primary focus on Hympavzi/ Vyndaqel and SCD. This position will be working closely with cross-functional teams (e.g., access, medical, clinical, commercial, etc.) to foster a culture that promotes innovation and thrives on doing better for Pfizer’s patients and society in general. This position will function in a closely aligned fashion with the Access team to ensure there is a single and coordinated view on strategy and project execution. This position will function with a One Pfizer mindset and will be expected to partner with Pfizer colleagues in various regional and national markets to ensure a consistent and robust evidence generation strategy. ROLE RESPONSIBILITIES Support the development of the Global HTA Value & Evidence Strategy in close partnership with Access and the cross-functional team. Manage execution of clinically relevant and scientifically valid Value & Evidence studies and projects (including non-interventional studies, registries, etc.) in alignment with the Global Value & Evidence Strategy to demonstrate the value proposition catered to diverse stakeholders (regulators, payers, patients, physicians, and policy makers)Lead updates of tools including global value dossiers (GV - Ds), economic models, and innovative tools to support value proposition. Develop real world evidence generation strategies and execute studies to support brand differentiation and value proposition. Lead the coordination of input from local country/regional Access & Value teams on evidence needs and ensure that input is appropriately incorporated to support demonstration of product value and optimize patient access. Lead the development of data dissemination plans and communicate, in a timely manner, evidence generated for various stakeholders via publications and conference presentations. Provide leadership on projects to ensure timely execution of PRO/ PCOA research to characterize patient outcomes, identify patient preferences and unmet needs, inform patient-focused measurement strategies, and develop and validate innovative patient-relevant outcomes measures and endpoints to differentiate Pfizer’s portfolio and meet business and global needs. Ensures the scientific quality and integrity of PRO research through development of rigorous qualitative and quantitative study research proposals, protocols, analysis plans and reports. BASIC QUALIFICATIONS -